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4 edition of Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity found in the catalog.

Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity

Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity

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Published by NASA in [Washington, D.C.] .
Written in English

    Subjects:
  • Musculoskeletal system,
  • Hindlimb -- Research,
  • Gravity -- Physiological effect,
  • Muscular atrophy

  • Edition Notes

    Other titlesJournal of applied physics 0021-8979.
    StatementKerry S. McDonald and Robert H. Fitts.
    SeriesNASA-CR -- 204850., NASA contractor report -- NASA CR-204850.
    ContributionsFitts, R. H.
    The Physical Object
    FormatMicroform
    Pagination1 microfiche (10 fr.)
    Number of Pages10
    ID Numbers
    Open LibraryOL17604916M
    OCLC/WorldCa47925116

    The space environment chiefly includes microgravity and radiation, which seriously threatens the health of astronauts. Bone loss and muscle atrophy are the two most significant changes in mammals after long-term residency in space. In this review, we summarized current understanding of the effects of microgravity and radiation on the musculoskeletal system and discussed the corresponding Cited by: 2. Hindlimb rat suspension is considered to be the model of choice for simulating the effects of hypoactivity and weightlessness, with its use having been described in > articles (17). With respect to the skeletal system, tail suspension is an appropriate model for bone disuse studies, as shown by Bloomfield et al. (3), who established a.

    A Metabolic Cage for the Hindlimb Suspended Rat J. EVANS, G. M. M ULENBURG, J. S. HARPER, T. L. S KUNDBERG, M. NAVIDI, AND S. B. ARNAUD Ames Research Center Introduction Hindlimb suspension has been successfully used to simu-late the effects of microgravity in rats. The cage and sus-pension system developed by Holton (ref. 1) is designed. Objective—To determine the accuracy of asymmetry indices of ground reaction forces (GRF) for diagnosis of hind limb lameness in dogs.. Animals—36 healthy dogs and 13 dogs with naturally acquired cranial cruciate ligament rupture or hip dysplasia.. Procedures—Lameness for affected dogs ranged from not detectable to minor and dogs trotted on an instrumented treadmill, GRF Cited by:

    To help clarify this issue, we determined, in chloralose-anesthetized cats, the effects on arterial pressure and heart rate of rhythmically contracting the hindlimb muscles at a frequency of 5 Hz. In addition, we determined the effect of rhythmic contractions on the impulse activity of group III and IV muscles afferents whose activation is Cited by: statically produce a certain amount of force/torque at the ground is not straightforward. A 3D musculoskeletal model of the cat hindlimb was created from cat cadaver measurements using Software for Interactive Musculoskeletal Systems (SIMM, Musculographics, Inc.). Six kinematic degrees of freedom and 31 individual hindlimb muscles were modeled.


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Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity Download PDF EPUB FB2

Get this from a library. Effect of hindlimb unloading on rat soleus fiber force, stiffness and calcium sensitivity. [Kerry S McDonald; R H Fitts; United States. National Aeronautics and Space Administration.]. In this work we studied changes in passive elastic properties of rat soleus muscle fibers subjected to 14 days of hindlimb unloading (HU).

For this purpose, we investigated the titin isoform. We here found that MFI in intrafusal fibers of soleus muscle in rats increased significantly after the short-term (3 d) hindlimb unloading, directly suggesting an increased amount of resting intracellular calcium.

After the 7-d hindlimb unloading, decreased buffer action to high calcium of CaBP might be related to the decrease in expression of Cited by: 8. Typical recordings from a ramp and hold stretch imposed to the rat soleus muscle with the Achilles tendon severed for the control and hindlimb unloading (HU) populations.

In these examples, the stretch had amplitude of 2 mm, was maintained for s and had a velocity of 50 mm/s. (a) Displacement tracings. (b) Passive by: 9. Effect of hindlimb unloading on resting intracellular calcium in intrafusal fibers and ramp-and-hold stretches evoked responsiveness of soleus muscle spindles in stiffness and calcium sensitivity book rats.

Effect of hindlimb unloading on resting intracellular calcium in intrafusal fibers and ramp-and-hold stretches evoked responsiveness of soleus muscle spindles in conscious rats.

Zhu Y(1), Fan X, Li X, Wu S, Zhang H, Yu by: 8. A state of disuse was produced in skeletal muscle by immobilizing both hindlimbs of the rat with plaster of paris. After 4 weeks of immobilization, the calcium concentration increased in the three different fiber types of the immobilized hindlimb.

The non-immobilized muscle of a rat showed no significant increase in calcium concentration when other limbs of the same rat were fixed by: Effect of hindlimb suspension on the functional properties of slow and fast soleus fibers from three strains of mice.

Stelzer JE(1), Widrick JJ. Author information: (1)Department of Exercise and Sport Science, Oregon State University, Corvallis, ORby:   Soleus muscle atrophy was induced by hindlimb suspension of rats for 3 weeks with the intention of inducing a relative increase in the percentage of fast twitch fibres and assessing modifications in muscle stiffness.

A method of dual controlled releases was used to obtain tension/extension curves and force/velocity relationships characterizing the mechanical behaviour of the by: Hindlimb unloading causes atrophy of all types of fibers in the rat soleus muscle (Ishihara et al.,).

Transformation of fibers from type I to IIA and decreased oxidative enzyme activity in all types of fibers are also observed in the rat soleus muscle after hindlimb unloading.

However,data pertaining to Cited by: and blood flow in the rat gastrocnemius-plantaris-soleus a/ter hindlimb suspension, J. Appl. Physiol. 73(3):The purpose of this study was to test the hypothesis that hindlimb suspension increases the fatigability of the soleus during intense contractile activity and determine whether theFile Size: KB.

Rats underwent hindlimb unloading for 14 days; this unloading duration has been shown to cause a significant loss of trabecular bone in Adult animals [11, 13], and this unloading period was previously used to examine bone loss in Aged rats.

Cortical and trabecular bone microstructure were assessed using micro-computed by: 4. MUSCLE FIBER TYPES AND FIBER MORPHOMETRY IN THE SOLEUS MUSCLE OF THE RAT Table 1.

Muscle fiber type percentages in the rat soleus muscle. Values given are means ± SD Sex N Type I Type IIA Ratio Mean SD Mean I/IIA M 5 F File Size: KB. In this work we studied changes in passive elastic properties of rat soleus muscle fibers subjected to 14 days of hindlimb unloading (HU).

For this purpose, we investigated the titin isoform expression in soleus muscles, passive tension-fiber strain relationships of single fibers, and the effects of the thick filament depolymerization on passive tension by: Effects of joint immobilization and hindlimb unloading on collagen fibers of soleus muscles in rats.

Tomohiro Matsumoto, Takeya Ono, Hideki Ishikura, Kazuki Control Group (CON, n=7); Joint Fixation Group (JF, n=7), Hindlimb Unloading Group (HU, n=7), Joint Fixation Plus Hindlimb Unloading Group (JF+HU, n=7). This study was conducted for by: 1. Effect of hindlimb unloading and reloading on the soleus and plantaris muscles in diabetic rats Journal of Physical Therapy Science, Vol.

30, No. 9 The response of Cited by: The right soleus muscle was used for histology and stained with hematoxylin eosin and the left soleus muscle was used to measure the MyoD and mechano growth factor mRNA expressions. [Result] Soleus muscle wet weights and cross-sectional areas of RL and WB were significantly greater than those of HS, although those of EX were by: 2.

Specifically, whereas hindlimb unweighting resulted in a significant loss of muscle protein in both the HLU and Heat+HLU groups, this effect was significantly (PCited by: Background Fibromyalgia (FM) is a chronic musculoskeletal pain disorder, characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances, however often with unknown etiology.

According to recent reports, physical and psychological stress trigger FM. To develop new treatments for FM, experimental animal models for FM are needed to be development. The differences in contractile force between fiber types is not simply a function of differences in cross-sectional area of the fibers.

Bodine et al. (Bodine et al., ) examined the effect of fiber type on specific tension and found significant differences Scaling of muscle architecture and fiber types in the rat hindlimb Carolyn M. Eng1. sensitivity of the skin to mechanical stimulation, epidermal thickness, peripheral nerve density in the upper dermis, and serum levels of a stress marker in a rat hindlimb suspension (HS) model.

Thirty 8-week-old male Wistar rats were randomly divided into 3 .title = "Modeling short-range stiffness of feline lower hindlimb muscles", abstract = "The short-range stiffness (SRS) of skeletal muscles is a critical property for understanding muscle contributions to limb stability, since it represents a muscle's capacity to resist external perturbations before reflexes or voluntary actions can by: Main Outcome Measures: Single skeletal muscle fiber contractile properties (diameter, peak active force [P0], peak specific tension [P0/CSA], and maximal shortening velocity [V0] by fiber type) were determined from the deep portion of the lateral head of the gastrocnemius muscle (RG).Cited by: